Nexium Generic
Esomeprazole is in a class of drugs called proton pump inhibitors PPIs which block the production of acid by the stomach. Other drugs in the same class include omeprazole Prilosec lansoprazole Prevacid rabeprazole Aciphex and pantoprazole Protonix. Chemically esomeprazole is very similar to omeprazole.
Proton pump inhibitors are used for the treatment of conditions such as stomach and duodenal ulcers
gastroesophageal reflux disease GERD and the Zollinger-Ellison syndrome which all are caused by stomach acid. Esomeprazole like other proton-pump inhibitors blocks the enzyme in the wall of the stomach that produces acid. By blocking the enzyme the production of acid is decreased and this allows the stomach and esophagus to heal. Esomeprazole was approved by the FDA n February 2001.how to useFor GERD 20 or 40 mg of esomeprazole is given once daily for 4-8 weeks.
For the treatment of H. pylori 40 mg is administered once daily in combination with amoxicillin and clarithromycin for 10 days.Esomeprazole capsules should be administered one hour before meals swallowed
whole and should not be crushed or chewed. Patients with difficulty swallowing can open the capsule and
mix the pellets with applesauce. The applesauce should not be hot and the pellets should not be chewed or
crushed.side effectsEsomeprazole like other PPIs is well-tolerated.The most common side effects are diarrhea
nausea vomiting headaches rash and dizziness. Nervousness abnormal heartbeat muscle pain weakness leg cramps and water retention occur infrequently.interaction Esomeprazole potentially can increase the
concentration in blood of diazepam by decreasing the elimination of diazepam in the liver. Esomeprazole may have fewer drug interactions than omeprazole.
The
absorption of certain drugs may be affected by
stomach acidity. Therefore esomeprazole and
other PPIs that reduce stomach acid also reduce
the absorption and concentration in blood of
ketoconazole Nizoral and increase the
absorption and concentration in blood of digoxin
Lanoxin.
This may lead to reduced effectiveness of
ketoconazole or increased digoxin toxicity
respectively.
usesEsomeprazole is approved for the treatment
of gastroesophageal reflux disease GERD and in
combination with amoxicillin and clarithromycin
Biaxin for the treatment of patients with
ulcers and H. pylori infection. Since it is very
similar to omeprazole it also is likely that it will
be used for the
treatment of Zollinger-Ellison
syndrome.
Esomeprazole is in a class of drugs called proton pump inhibitors PPIs which block the production of acid by the stomach. Other drugs in the same class include omeprazole Prilosec lansoprazole Prevacid rabeprazole Aciphex and pantoprazole Protonix. Chemically esomeprazole is very similar to omeprazole.
Proton pump inhibitors are used for the treatment of conditions such as stomach and duodenal ulcers
gastroesophageal reflux disease GERD and the Zollinger-Ellison syndrome which all are caused by stomach acid. Esomeprazole like other proton-pump inhibitors blocks the enzyme in the wall of the stomach that produces acid. By blocking the enzyme the production of acid is decreased and this allows the stomach and esophagus to heal. Esomeprazole was approved by the FDA n February 2001.how to useFor GERD 20 or 40 mg of esomeprazole is given once daily for 4-8 weeks.
For the treatment of H. pylori 40 mg is administered once daily in combination with amoxicillin and clarithromycin for 10 days.Esomeprazole capsules should be administered one hour before meals swallowed
whole and should not be crushed or chewed. Patients with difficulty swallowing can open the capsule and
mix the pellets with applesauce. The applesauce should not be hot and the pellets should not be chewed or
crushed.side effectsEsomeprazole like other PPIs is well-tolerated.The most common side effects are diarrhea
nausea vomiting headaches rash and dizziness. Nervousness abnormal heartbeat muscle pain weakness leg cramps and water retention occur infrequently.interaction Esomeprazole potentially can increase the
concentration in blood of diazepam by decreasing the elimination of diazepam in the liver. Esomeprazole may have fewer drug interactions than omeprazole.
The
absorption of certain drugs may be affected by
stomach acidity. Therefore esomeprazole and
other PPIs that reduce stomach acid also reduce
the absorption and concentration in blood of
ketoconazole Nizoral and increase the
absorption and concentration in blood of digoxin
Lanoxin.
This may lead to reduced effectiveness of
ketoconazole or increased digoxin toxicity
respectively.
usesEsomeprazole is approved for the treatment
of gastroesophageal reflux disease GERD and in
combination with amoxicillin and clarithromycin
Biaxin for the treatment of patients with
ulcers and H. pylori infection. Since it is very
similar to omeprazole it also is likely that it will
be used for the
treatment of Zollinger-Ellison
syndrome.
